新型冠状病毒肺炎(COVID-19)治疗方案中α-干扰素使用的评价

庞宁, 杨丽, 赵荣生

中国药学杂志 ›› 2020, Vol. 55 ›› Issue (10) : 777-782.

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中国药学杂志 ›› 2020, Vol. 55 ›› Issue (10) : 777-782. DOI: 10.11669/cpj.2020.10.004
新冠疫情防控专栏

新型冠状病毒肺炎(COVID-19)治疗方案中α-干扰素使用的评价

  • 庞宁, 杨丽, 赵荣生*
作者信息 +

Evaluation of α-Interferon Applied in COVID-19 Therapy Regimen

  • PANG Ning, YANG Li, ZHAO Rong-sheng*
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文章历史 +

摘要

目的 新型冠状病毒肺炎(COVID-19)暴发引起广泛关注,国家卫生健康委员会诊疗方案中推荐α-干扰素(IFN-α)雾化吸入治疗,但目前尚无IFN-α的雾化吸入剂型,超说明书用药的可行性值得探讨。方法 笔者回顾了SARS和MERS临床研究,据此讨论COVID-19治疗中IFN的有效性和安全性。通过雾化吸入特点、IFN-α的性质及其临床研究对IFN-α雾化吸入的可行性进行分析。结果 IFN-α可缓解疾病的早期症状,但可能不显著影响危重患者死亡率,仍需开展更多随机对照临床研究;选择适宜的雾化装置及药液浓度后IFN-α的活性无明显变化,但由于缺乏必要的辅料,其体内吸收利用效果不佳,注射液中辅料成分有增加不良反应的风险。结论 IFN-α注射液雾化吸入应充分评估风险,缺乏适宜雾化装置或操作人员时,可尝试性选择皮下注射的给药方式。

Abstract

OBJECTIVE To use IFNα injection as inhalant for there is no proper dosage form for aerosol inhalation and evaluate the feasibility of IFN-α off-label use. METHODS The clinical studies in SARS and MERS were reviewed to discuss the efficacy and safety of IFN-α application in COVID-19. Meanwhile, the features of aerosol inhalation, characteristics of IFN-α and related clinical researches were analyzed to argue the possibility of IFN-α aerosol inhalation. RESULTS IFN-α seems to be effective in relieving early symptoms but likely invalid in reducing mortality of severe patients, however, the exact therapeutic effect calls for further clinical tests. Proper atomization of IFN-α injection won't reduce biological activity of the protein, but absorption and utilization of IFN-α in lung may be unsatisfactory for the lack of sorbefacient. More than that, ingredients in IFN-α injection may increase risk of adverse reaction. CONCLUSION The aerosol inhalation of IFN-α injection should be fully evaluated on the side of patients. If there is a lack of proper atomization device or operation staff, subcutaneous injection of IFN-α may be a tentative administration.

关键词

新型冠状病毒肺炎 / α-干扰素 / 雾化吸入 / 给药途径 / 治疗评估

Key words

COVID-19 / α-interferon / aerosol inhalation / administration route / therapy evaluation

引用本文

导出引用
庞宁, 杨丽, 赵荣生. 新型冠状病毒肺炎(COVID-19)治疗方案中α-干扰素使用的评价[J]. 中国药学杂志, 2020, 55(10): 777-782 https://doi.org/10.11669/cpj.2020.10.004
PANG Ning, YANG Li, ZHAO Rong-sheng. Evaluation of α-Interferon Applied in COVID-19 Therapy Regimen[J]. Chinese Pharmaceutical Journal, 2020, 55(10): 777-782 https://doi.org/10.11669/cpj.2020.10.004
中图分类号: R97   

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